John W Hanrahan Selected Research

Anions

12/2021	Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.
1/2021	Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis.
12/2020	The Phosphodiesterase Inhibitor Ensifentrine Reduces Production of Proinflammatory Mediators in Well Differentiated Bronchial Epithelial Cells by Inhibiting PDE4.
1/2019	Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.
1/2019	Pendrin Mediates Bicarbonate Secretion and Enhances Cystic Fibrosis Transmembrane Conductance Regulator Function in Airway Surface Epithelia.
1/2019	Hsp70 and DNAJA2 limit CFTR levels through degradation.
1/2019	Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains.
2/2016	Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).
7/2015	Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells.
11/2013	The secret life of CFTR as a calcium-activated chloride channel.

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John W Hanrahan Research Topics

Disease

39	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 09/2003
5	Inflammation (Inflammations) 01/2021 - 01/2012
4	Infections 12/2020 - 10/2007
3	Lung Diseases (Lung Disease) 01/2022 - 01/2021
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2016 - 11/2012
2	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2014 - 11/2012
1	Fatigue 01/2022
1	Hypoxia (Hypoxemia) 01/2021
1	Bacterial Infections (Bacterial Infection) 01/2020
1	Asthma (Bronchial Asthma) 01/2016
1	Fibrosis (Cirrhosis) 01/2016
1	Dehydration (Water Stress) 10/2013
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2013
1	Pneumonia (Pneumonitis) 11/2012
1	Muscular Atrophy (Muscle Atrophy) 07/2009
1	Opportunistic Infections (Opportunistic Infection) 09/2004
1	Chronic Pancreatitis 09/2003
1	Bronchiectasis 09/2003

Drug/Important Bio-Agent (IBA)

16	AnionsIBA 12/2021 - 10/2007
15	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2022 - 09/2003
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2011
4	CytokinesIBA 01/2021 - 07/2009
3	LipidsIBA 01/2022 - 01/2021
3	Phenobarbital (Luminal)FDA Link 01/2021 - 06/2012
2	Chloride Channels (Chloride Channel)IBA 01/2022 - 11/2012
2	Bicarbonates (Hydrogen Carbonate)IBA 01/2021 - 10/2013
2	SaltsIBA 12/2020 - 06/2012
2	CeramidesIBA 01/2019 - 10/2017
2	Phenylalanine (L-Phenylalanine)FDA Link 01/2019 - 01/2012
2	EnzymesIBA 10/2017 - 01/2012
2	Pharmaceutical PreparationsIBA 01/2017 - 01/2016
1	CholesterolIBA 01/2022
1	Adhesives (Glues)IBA 01/2022
1	Expectorants (Mucolytics)IBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Bronchodilator Agents (Bronchodilators)IBA 01/2022
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 12/2021
1	BuffersIBA 01/2021
1	Cyclic NucleotidesIBA 01/2021
1	Phosphodiesterase InhibitorsIBA 01/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021
1	ChemokinesIBA 12/2020
1	MucinsIBA 01/2020
1	lumacaftorIBA 01/2018
1	Cholinergic Agents (Cholinergics)IBA 01/2018
1	SmokeIBA 01/2018
1	dihydroceramide desaturaseIBA 10/2017
1	ZincIBA 10/2017
1	FenretinideIBA 10/2017
1	ThymosinIBA 01/2017
1	ChloridesIBA 01/2017
1	ensifentrineIBA 01/2016
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2016
1	Environmental Pollutants (Pollutants, Environmental)IBA 01/2014
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2013
1	Mutant Proteins (Protein, Mutant)IBA 01/2013
1	Ouabain (G Strophanthin)IBA 01/2012
1	Interleukin-8 (Interleukin 8)IBA 12/2011
1	UbiquitinIBA 07/2009
1	Ligases (Synthetase)IBA 07/2009
1	CalciumIBA 07/2009
1	cystic fibrosis transmembrane conductance regulator delta F508IBA 04/2009
1	AllergensIBA 11/2008
1	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 10/2007
1	Carbachol (Carbastat)FDA Link 10/2007
1	Antimicrobial PeptidesIBA 09/2004
1	1,25-dihydroxyvitamin DIBA 09/2004
1	DNA (Deoxyribonucleic Acid)IBA 09/2003

Therapy/Procedure

7	Therapeutics 01/2022 - 02/2008
1	Drug Therapy (Chemotherapy) 10/2020